Evaluation of cytogenetic effects on bovine peripheral lymphocytes after the treatment with tebuconazole

Document Type : Original Article

Authors

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

Abstract

Tebuconazole-based fungicide (group of triazole fungicides, with 25% of active agent) was evaluated for their ability to induce sister chromatid exchange (SCE) and proliferation indices (PI) in cultured bovine peripheral lymphocytes. The cultures were treated with the fungicides at the concentrations ranged from 3 to 60 µg.ml-1 for the last 24 and 48 h of incubation. Positive results in the SCE induction were obtained after the exposure to tebuconazole for the last 24h of incubation. The highest concentration of the fungicide also reflected in reduction of proliferation activity, but only insufficient number of cells could be analysed. Our results correspond to our previous finding from the CA assay (chromosomal aberrations) in bovine peripheral lymphocytes treated with the fungicide. Prolonged time of exposure provided inadequate evidence for the genotoxic activity of the fungicide.

Keywords

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control
Volume 2, Issue 2
December 2010
Pages 1-4

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