Effect of Dietary Curcumin on Heptorenal Afla-Toxicosis in Mice

Abdelrazek, Heba M. A.; Zeidan, Dalia W.; Soliman, Mohamed T. A.; Khodry, Alaa Kh. A.

doi:10.21608/eajbsf.2018.31091

Effect of Dietary Curcumin on Heptorenal Afla-Toxicosis in Mice

Document Type : Original Article

Authors

¹ -Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

² Department of Home and Economics, Nutrition and Food Science Branch, Faculty of Education, Suez Canal University, Egypt

³ College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Bisha 61922, p.o. Box 551, Kingdom of Saudi Arabia.

⁴ -Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

10.21608/eajbsf.2018.31091

Abstract

Mycotoxins contribute great adverse health concerns, especially on liver and kidney. The current study aimed to investigate the possible protective effect of dietary curcumin on hepatorenal aflatoxicosis in mice. Thirty-two male albino mice 18-20 g were divided into 4 groups. Group I, is the control group received basal diet. Group II, received a basal diet with 2% curcumin. Group III, given a basal diet with added AFs (5 µg/kg). Group IV, co-administered AFs and curcumin at the same previous doses. All treatments continued for 4 weeks. Liver and kidney weights, as well as food conversion ratio (FCR), were determined. The serum levels of Superoxide dismutase (SOD), total antioxidant capacity (TAC), Malondialdehyde (MDA) and Interleukin-6 (IL-6) were estimated. Serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin and creatinine were estimated. Histopathological examination to liver and kidney was performed. AFs significantly increased FCR and liver weight than control. The levels of SOD and TAC significantly reduced in-group III while MDA and IL-6 increased than control. The levels of AST, ALT and creatinine were significantly (P<0.05) increased in AFs group meanwhile albumin was significantly reduced than control. Hepatic and renal tissue showed congestion, lymphocytic infiltrations and other retrogressive changes. The co-administration of curcumin with AFs significantly ameliorated the AFs induced adverse effects. Curcumin possesses antioxidant effect that ameliorated aflatoxicosis adverse effects on the kidney and liver.

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