Assessment of the Potential Therapeutic Role of Methanolic Extract for Cichorium intybus and Portulaca oleracea against H2O2-Induced Toxicity

Document Type : Original Article

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Biochemistry Department, Faculty of Agriculture, Menoufia University, Menoufia, Egypt.

Abstract

Cichorium intybus (CI) and Portulaca oleracea (PO) are considered rich sources of bioactive compounds. In the current study, the potential therapeutic effect of CI and PO was assessed by using two concentrations (150 and 300 mg/kg bw) of their methanolic extract against H2O2-induced toxicity in male albino rats. To this end, we carried out the liver function tests [Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), Gama-glutamyl transferase (g-GT), and Albumin], the renal function tests [Creatinine, Urea], the oxidative stress biomarkers [superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA)] in the plasma of the experimental animals. After the toxicity with H2O2, the two mentioned concentrations (with time and dose-dependent) of either CI or PO ameliorated the resulting damage significantly compared to the control group. For example, the levels of hepatic, renal biomarkers, and oxidative stress parameters showed a significant improvement. To conclude, the methanolic extracts of CI and PO form promising medical agents against the harmful effect induced by H2O2 toxicity. 

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