tudy of the Role of the Antioxidants;Silymarin and Vitamin C in Treatment ofthe Indomethacin-Induced Gastric Ulcer in Rats

Document Type : Original Article

Authors

Pharmacology Department, Faculty of Medicine, Al-Azhar University (Assiut)

Abstract

Gastric ulcer represents a serious medical problem largely due to its frequency and high economic cost. Its incidence amounts up to 10% of the population in developed countries. Severe stress, Helicobacter pylori infection, ingestion of alcohol, aspirin and other NSAIDs are predisposing factors. Some studies have implicated the involvement of oxygen-derived free radicals in the pathogenesis of gastric ulcers and showed that antioxidants protect against gastro-duodenal injury. The present work was designed to evaluate the potential healing properties of the known antioxidants; silymarin and vitamin C as compared with omeprazole in the indomethacin-induced gastric ulcer in male albino rats. The present study showed that i.p administration of indomethacin (20m/kg) for two successive days produced several necro-hemorrhagic lesions in the gastric mucosa associated with decrease of the antioxidant parameters; Glutathione and Superoxide and increase of the gastric juice and total acid output. Treatment with silymarin (50 mg/kg/day), vitamin C (200 mg/kg/ day) and omeprazole (3.6 mg/kg/day) for 5 days reduced the mean ulcer index, the oxidant parameter, malondialdehyde, the total gastric volume, the titratable acidity and total acid output and increased the antioxidant parameters; glutathione andsuperoxide dismutase.
In conclusion, silymarin and vitamin-c produced a significant healing effect in the indomethacin-induced gastric ulceration in male albino rats.

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